Transthyretin variants with improved inhibition of β-amyloid aggregation
نویسندگان
چکیده
منابع مشابه
Mechanisms of transthyretin inhibition of β-amyloid aggregation in vitro.
Tissue-specific overexpression of the human systemic amyloid precursor transthyretin (TTR) ameliorates Alzheimer's disease (AD) phenotypes in APP23 mice. TTR-β-amyloid (Aβ) complexes have been isolated from APP23 and some human AD brains. We now show that substoichiometric concentrations of TTR tetramers suppress Aβ aggregation in vitro via an interaction between the thyroxine binding pocket of...
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Protein aggregation is a hallmark of many neurodegenerative disorders. Alzheimer's disease (AD) is directly linked to deposits of amyloid-β (Aβ) derived from the amyloid-β protein precursor (AβPP), and multiple experimental studies have investigated the aggregation behavior of these amyloids. The present paper reports modeling of the aggregation propensities and cell toxicities of genetic varia...
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ژورنال
عنوان ژورنال: Protein Engineering Design and Selection
سال: 2016
ISSN: 1741-0126,1741-0134
DOI: 10.1093/protein/gzw008